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Nicotinamide Mononucleotide CAS#1094-61-7

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Chemical Name:Nicotinamide Mononucleotide

CAS No.1094-61-7

Molecular Formula:C11H15N2O8P

Molecular weight: 334.22

Sample: Available

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Product Details

Products Description of Nicotinamide Mononucleotide CAS#1094-61-7

Nicotinamide mononucleotide, also known as β-nicotinamide mononucleotide (NMN), is a synthetic substrate of coenzyme I. At the same time, NMN is also used in anti-aging research. Studies have shown that β-NMN can also regulate the secretion of insulin and affect the expression level of mRNA. β-NMN has broad application prospects in the field of medical treatment. β-Nicotinamide mononucleotide is a product of the extracellular nicotinamide phosphoribosyltransferase (eNAMPT) reaction and a key NAD+ intermediate. It improves glucose tolerance by restoring NAD+ levels in HFD-induced T2D mice. It also enhances hepatic insulin sensitivity and restores gene expression related to oxidative stress, inflammatory response and circadian rhythm in part through SIRT1 activation.

β-Nicotinamide Mononucleotide Chemical Properties

Melting point	166 °C(dec.)
storage temp.	-20°C
solubility	DMSO (Slightly, Heated), Methanol (Slightly), Water (Slightly)
form	Solid
color	White to Yellow
Merck	13,6697
BRN	3570187
Stability:	Very Hygroscopic
InChI	InChI=1/C11H15N2O8P/c12-10(16)6-2-1-3-13(4-6)11-9(15)8(14)7(21-11)5-20-22(17,18)19/h1-4,7-9,11,14-15H,5H2,(H3-,12,16,17,18,19)/t7-,8-,9-,11-/s3
InChIKey	DAYLJWODMCOQEW-TURQNECASA-N
SMILES	O[C@@H]1[C@@H]([C@@H](COP(O)([O-])=O)O[C@H]1[N+]1=CC=CC(C(=O)N)=C1)O \|&1:1,2,3,11,r\|

Safety Information

WGK Germany	3
F	8-10-21
HS Code	2934999090

Product Application of Nicotinamide Mononucleotide CAS#1094-61-7

β-Nicotinamide mononucleotide is the precursor of NAD+, a cofactor of longevity proteins in the human body. NAD+ is an important coenzyme in the tricarboxylic acid cycle, promoting the metabolism of sugars, fats, and amino acids, and participating in the synthesis of energy; NAD+ is also the only substrate of coenzyme I consuming enzymes (the only substrate of DNA repair enzyme PARP, the only substrate of longevity protein Sirtuins, and the only substrate of cyclic ADP ribose synthetase CD38/157). NAD+ participates in all aspects of human metabolism and is a key coenzyme. Without NAD+, metabolism will not work. Elderly people lack NAD+, so various major and minor problems come. By supplementing NAD+, comprehensive anti-aging can be achieved. Preclinical studies have shown that NMN has multiple pharmacological activities in cardiac and cerebral ischemia, Alzheimer's disease, type 2 diabetes and obesity caused by diet and age. As a precursor drug of NAD+, NMN mainly synthesizes NAD+ in the body to exert pharmacological effects, all of which are related to the lack of NAD+.

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