Nicotinamide CAS#98-92-0

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Chemical Name:Nicotinamide  

CAS No.:98-92-0 

Molecular Formula:C6H6N2O

Molecular weight:122.12

Sample: Available

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Product Details

Products Description of Nicotinamide CAS#98-92-0

Nicotinamide, also known as nicotinamide, vitamin B3 or vitamin PP, is a water-soluble vitamin belonging to the B vitamins. It is a component of coenzyme I (nicotinamide adenine dinucleotide, NAD) and coenzyme II (nicotinamide adenine dinucleotide phosphate, NADP). The nicotinamide part of these two coenzyme structures in the human body has reversible hydrogenation and dehydrogenation properties, plays a role in hydrogen transfer in biological oxidation, can promote tissue respiration, biological oxidation process and metabolism, and is of great significance to maintaining the integrity of normal tissues, especially the skin, digestive tract and nervous system. When it is deficient, pellagra is caused due to the impact on cell respiration and metabolism, so this product is mainly used to prevent and treat pellagra, stomatitis, glossitis, etc.


Nicotinamide Chemical Properties

Melting point 

128-131 °C(lit.)

Boiling point 

150-160 °C

density 

1.40

vapor density 

4.22 (vs air)

vapor pressure 

0Pa at 25℃

refractive index 

1.4660 (estimate)

Fp 

182 °C

storage temp. 

2-8°C

solubility 

691g/l

pka

3.3(at 20℃)

form 

powder

color 

white

PH

6.0-7.5 (50g/l, H2O, 20℃)

Odor

Odorless

PH Range

9

Water Solubility 

1000 g/L (20 ºC)

Decomposition 

>=200 °C

Merck 

14,6523

BRN 

383619

BCS Class

1

Stability:

Stable. Incompatible with strong oxidizing agents.

InChIKey

DFPAKSUCGFBDDF-UHFFFAOYSA-N

LogP

-0.38 at 21℃

CAS DataBase Reference

98-92-0(CAS DataBase Reference)

NIST Chemistry Reference

Niacinamide(98-92-0)

EPA Substance Registry System

Nicotinamide (98-92-0)

Safety Information

Hazard Codes 

Xi,T,F

Risk Statements 

36/37/38-39/23/24/25-23/24/25-11

Safety Statements 

26-36-37/39-45-36/37-16-7

RIDADR 

UN1230 - class 3 - PG 2 - Methanol, solution

WGK Germany 

1

RTECS 

QS3675000

8

Autoignition Temperature

480 °C

TSCA 

Yes

HS Code 

29362990

Hazardous Substances Data

98-92-0(Hazardous Substances Data)

Toxicity

LD50 s.c. in rats: 1.68 g/kg (Brazda, Coulson)

Product Application of Nicotinamide CAS#98-92-0

1. Moisturizing, oil control, and reducing blackheads Niacinamide can effectively reduce transepidermal water loss. Although the effect of using it alone is not as good as that of hyaluronic acid and glycerin, the effect of using it together is definitely 1+1>2; Niacinamide can calm down the sebaceous glands in an "excited" state, thereby achieving the effect of controlling oil and reducing blackheads and acne.

2. Good anti-wrinkle ability Niacinamide's anti-wrinkle ability lies in its ability to activate ATP, provide vitality to keratinocytes, increase collagen synthesis, and has good synergistic ability, and can be used with other anti-wrinkle ingredients.

3. Good auxiliary sunscreen effect The harm caused by ultraviolet rays to the human body is not only tanning, but also leads to immunosuppression and even skin cancer. Many studies at home and abroad have shown that niacinamide can effectively reduce the occurrence of skin photoimmunosuppression during ultraviolet irradiation.

4. Good mildness Compared with ingredients such as vitamin C and resorcinol derivatives, niacinamide is quite mild, and many people's skin types can basically use it, but you still need to pay attention to the problem of skin tolerance. For example, the 10% niacinamide concentration of The Ordinary whitening essence is still irritating. Therefore, it is best to undergo a skin tolerance test before use to confirm tolerance before starting use. At the same time, be careful not to use it with acid-containing products, such as salicylic acid and fruit acid, to prevent excessive irritation to the skin.



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