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Shikonin CAS#517-89-5

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Chemical Name：Shikonin

CAS No.:517-89-5

Molecular Formula：C16H16O5

Molecular weight:288.3

Sample: Available

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Product Details

Products Description of Shikonin CAS#517-89-5

Shikonin (shikonin, shikonin, shikonin) is a class of natural products with naphthoquinone structure extracted from the root of Lithospermum officinale, which has anti-inflammatory, antioxidant, anti-tumor, and wound healing effects. In recent years, the anti-tumor effects of shikonin and its derivatives have been widely studied.

Several in vitro and in vivo studies have shown that shikonin and its derivatives can effectively inhibit the occurrence and development of gynecological malignancies such as breast cancer and cervical cancer. Shikonin exerts a powerful anticancer effect on various types of cancer by inhibiting cell proliferation and migration, inducing cell apoptosis, autophagy and necroptosis. Shikonin can also trigger the production of reactive oxygen species (ROS), inhibit exosome release, and activate anti-tumor immunity through multiple molecular mechanisms.

Examples of these effects include regulating PI3K/AKT/mTOR and MAPKs signal transduction; inhibiting the activation of TrxR1, PKM2, RIP1/3, Src and FAK; and regulating ERP57, MMP, ATF2, C-MYC, miR-128 and GRP78 (Bip)

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Shikonin Chemical Properties

Melting point	148℃
Boiling point	567.4±50.0 °C(Predicted)
density	1.373±0.06 g/cm3(Predicted)
storage temp.	-20°C
solubility	DMSO : ≥ 31 mg/mL (107.53 mM);
pka	7.34±0.20(Predicted)
form	Red crystalline solid.
color	Brown
LogP	4.350 (est)
CAS DataBase Reference	517-89-5(CAS DataBase Reference)

Safety Information

Risk Statements	20/21/22-50/53-20
Safety Statements	26-36/37/39-61
RIDADR	3077
HS Code	29146990
Hazardous Substances Data	517-89-5(Hazardous Substances Data)

Product Application of Shikonin CAS#517-89-5

Edible purple pigment. Used for coloring spicy meat and poultry cans, dosage 0.35-0.56g/kg. Put the crushed lithospermum into a fine sieve, pour 160-170℃ hot oil on it, so that the pigment dissolves in the oil. The oil flows out through the fine sieve, mixes with the chili powder in the container, and after fully stirring, boils into a mixed sauce for later use.

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