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Hydroxychloroquine sulfate CAS#747-36-4

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Chemical Name：Hydroxychloroquine sulfate

CAS No.747-36-4

Molecular Formula：C18H28ClN3O5S

Molecular weight:433.95

Sample: Available

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Product Details

Products Description of Hydroxychloroquine sulfate CAS#747-36-4

Hydroxychloroquine sulfate is an antimalarial drug that also has anti-inflammatory, immunomodulatory and anticoagulant effects. Currently, hydroxychloroquine is mainly used in the treatment of rheumatoid arthritis, juvenile chronic arthritis, discoid lupus erythematosus and systemic lupus erythematosus, but the clinical effect is slow, often requiring 2 to 4 months. The pharmacological action of this drug is not very clear. It may be related to stabilizing lysosomal membranes, inhibiting the formation of prostaglandins, inhibiting the chemotaxis of polymorphonuclear cells and the action of phagocytes, and may interfere with the formation of monocyte interleukin-1 and inhibit the release of neutrophil superoxide.

Hydroxychloroquine sulfate Chemical Properties

Melting point	240 °C
storage temp.	protect from light
solubility	H2O: >20mg/mL
form	Crystalline Powder
color	white to off-white
Water Solubility	FREELY SOLUBLE
Merck	14,4818
Stability:	Stable for 2 years from date of purchase as supplied. Solutions in water may be stored at -20°C for up to 3 months.
InChIKey	JCBIVZZPXRZKTI-UHFFFAOYSA-N
EPA Substance Registry System	Ethanol, 2-[[4-[(7-chloro-4-quinolinyl)amino]pentyl]ethylamino]-, sulfate (1:1) (747-36-4)

Safety Information

Hazard Codes	Xn,Xi
Risk Statements	42/43-36/37/38-36-22
Safety Statements	37/39-26
WGK Germany	3
RTECS	KK3342500
HS Code	29334990

Product Application of Hydroxychloroquine sulfate CAS#747-36-4

①Each dose should be taken with food or milk.

②Hydroxychloroquine sulfate has a cumulative effect and takes several weeks to exert its beneficial effects, while mild adverse reactions may occur relatively early.

③If rheumatic diseases do not improve after 6 months of treatment, treatment should be terminated. In the case of photosensitive diseases, treatment should be given only under maximum exposure to sunlight.

④All patients should undergo an ophthalmological examination before starting treatment with this product. It is contraindicated in patients with preexisting macular lesions.

⑤Favism, psoriasis, etc. should be used with caution.

⑥Pregnant women should avoid the use of hydroxychloroquine.

⑦The combination of hydroxychloroquine with other arrhythmogenic drugs (e.g., amiodarone and moxifloxacin) may increase the risk of inducing ventricular arrhythmias.

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