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Homopiperazine CAS#505-66-8

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Chemical Name:Homopiperazine

CAS No.505-66-8

Molecular Formula:C5H12N2

Molecular weight: 100.16

Sample: Available

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Product Details

Products Description of Homopiperazine CAS#505-66-8

Homopiperazine is a nitrogen-containing seven-membered ring compound and an important pharmaceutical intermediate. Most of its derivatives have strong biological activity and medicinal value and can be used to synthesize drugs such as homopiperazine hydrochloride, cyclizine, carbamazepine, quinolones and chlorcyclizine. Western medicine uses homopiperazine as a raw material to modify quinoline and isoquinoline derivatives, quinolone derivatives, thiazolidine hydroxy acid amide derivatives and other drugs, and drugs used to synthesize pyridazineamine, nitroxyl-containing benzylamine derivatives, water-soluble azoles, etc., which show good therapeutic effects on the treatment of cardiovascular diseases, interstitial plasma cell pneumonia, especially interstitial plasma cell pneumonia in AIDS patients, asthma, central nervous system diseases including depression and anxiety. For example, 1-(5-isoquinolinesulfonyl) homopiperazine hydrochloride can effectively treat symptoms such as chronic angina, vitiligo, depression, anxiety, cerebral vasospasm and cerebral ischemia caused by cerebral vasospasm.

Homopiperazine Chemical Properties

Melting point	38-40 °C (lit.)
Boiling point	169 °C (lit.)
density	0.95
refractive index	1.4378 (estimate)
Fp	148 °F
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
solubility	Chloroform (Sparingly), Ethyl Acetate (Slightly), Methanol (Slightly)
form	Crystalline Mass
pka	11.02±0.20(Predicted)
color	White to light yellow
Water Solubility	Soluble in water.
Sensitive	Air Sensitive & Hygroscopic
BRN	102711
CAS DataBase Reference	505-66-8(CAS DataBase Reference)
NIST Chemistry Reference	Homopiperazine(505-66-8)
EPA Substance Registry System	1H-1,4-Diazepine, hexahydro- (505-66-8)

Safety Information

Hazard Codes	C,Xi
Risk Statements	21-34
Safety Statements	26-36/37/39-45-27
RIDADR	UN 3259 8/PG 2
WGK Germany	1
RTECS	HM3850000
F	3-10-23
Hazard Note	Irritant/Corrosive
TSCA	Yes
HazardClass	8
PackingGroup	III
HS Code	29339900

Product Application of Homopiperazine CAS#505-66-8

Homopiperazine and its derivatives have become important drug intermediates, showing great potential for sedation, antipsychotic, anti-inflammatory and anti-neurosis. They are important products that connect the chemical industry and the pharmaceutical industry and are widely used in the fields of medicine, pesticides, surfactants, and energetic materials. Homopiperazine derivatives, in which the hydrogen atom on the amino group in the molecule is replaced by a long-chain alkyl or alkoxy group, can be used as wetting agents, emulsifiers, detergents, and colorants; Homopiperazine and its derivatives can be used as oxidative colorants because they contain dyed keratin fibers, have bright colors and high fastness properties, and play an important role in dyeing, especially the dyeing of human hair.

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