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Clotrimazole CAS#23593-75-1

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Chemical Name：Clotrimazole

CAS No.:23593-75-1

Molecular Formula：C22H17ClN2

Molecular weight:344.84

Sample: Available

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Product Details

Products Description of Clotrimazole CAS#23593-75-1

Clotrimazole is a synthetic azole antifungal drug that has inhibitory effects on a variety of pathogenic fungi and can also have a bactericidal effect at high concentrations. Clotrimazole inhibits the biosynthesis of fungal ergosterol and other sterols by interfering with the activity of cytochrome P450;

It damages the fungal cell membrane and changes its permeability, causing the leakage of important substances in the cell;

It can also inhibit the biosynthesis of triglycerides and phospholipids in fungi;

This product can also inhibit the activity of oxidation and peroxidase, causing excessive accumulation of peroxides in cells, causing degeneration and necrosis of fungal subcellular structures.

Clotrimazole has a broad-spectrum antifungal activity, and has good antibacterial effects on epidermophyton, trichophyton, aspergillus, pigmented fungi, cryptococcus and candida, and also has certain antibacterial activity against sporotrichosis schenckii, blastomyces dermatitidis, coccidioides immitis, histoplasma, etc.

Clotrimazole Chemical Properties

Melting point	147-149°C
Boiling point	501.14°C (rough estimate)
density	1.1095 (rough estimate)
refractive index	1.5940 (estimate)
storage temp.	2-8°C
solubility	Soluble in chloroform, DMSO, DMF and alcohols
pka	pKa 4.7(EtOH 50%aq ) (Uncertain)
color	White to Almost white
Water Solubility	<10mg/L(25 ºC)
λmax	556nm(Phosphate buffer sol.)(lit.)
Merck	14,2417
InChI	InChI=1S/C22H17ClN2/c23-21-14-8-7-13-20(21)22(25-16-15-24-17-25,18-9-3-1-4-10-18)19-11-5-2-6-12-19/h1-17H
InChIKey	VNFPBHJOKIVQEB-UHFFFAOYSA-N
SMILES	C1N(C(C2=CC=CC=C2Cl)(C2=CC=CC=C2)C2=CC=CC=C2)C=CN=1
NIST Chemistry Reference	Clotrimazole(23593-75-1)

Safety Information

Hazard Codes	Xn
Risk Statements	22-36/38
Safety Statements	26-36
WGK Germany	3
RTECS	NI4377000
HS Code	29332900
Hazardous Substances Data	23593-75-1(Hazardous Substances Data)
Toxicity	LD50 in male mice, rats (mg/kg): 923, 708 orally (Tettenborn)

Product Application of Clotrimazole CAS#23593-75-1

Clinical topical application of 1% clotrimazole cream or solution is used to treat skin infections such as candidal tinea, tinea versicolor, tinea pedis, and tinea unguium. Clotrimazole vaginal tablets (100 mg) can be used to treat vaginal infections caused by Candida and Trichomonas. Side effects include local irritation and burning sensation. Oral administration is used to treat deep fungal infections, but the side effects are more severe, including gastrointestinal irritation, neutropenia, and abnormal liver function.

1. Oral administration: (1) For the treatment of oropharyngeal candidal infections. (2) For the prevention of oropharyngeal candidal infections in patients undergoing chemotherapy or with immunosuppression or deficiency.

2. Topical application: (1) Candidal skin infections. (2) Tinea manuum, pedis, tinea cruris, and tinea corporis caused by Trichophyton, Microsporum, and Epidermophyton; Tinea versicolor caused by Pityrosporum.

3. Vaginal administration: (1) Vaginitis caused by Candida or other fungi. (2) Infectious leucorrhea caused by yeast. (3) Superinfection of the vagina caused by bacteria sensitive to this drug.

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