< >

(2S)-1-(Chloroacetyl)-2-pyrrolidinecarbonitrile CAS#207557-35-5

(2S)-1-(Chloroacetyl)-2-pyrrolidinecarbonitrile CAS#207557-35-5 Promotion Season Now in Store and Free Sample for Testing with Factory Price

Chemical Name：(2S)-1-(Chloroacetyl)-2-pyrrolidinecarbonitrile

CAS No.:207557-35-5

Molecular Formula：C7H9ClN2O

Molecular weight:172.61

Sample: Available

Mode of Transportation

1. By Air, fast but expensive.

2. By Sea, usual and economy.

3. By Train, suit for middle Asia countries.

4. By Express, suit for small package.

We only provide highest quality goods available, accompanied by after support!

Contact Now E-Mail Telephone WhatsApp

Product Details

Products Description of (2S)-1-(Chloroacetyl)-2-pyrrolidinecarbonitrile CAS#207557-35-5

(2S)-N-Chloroacetyl-2-cyanopyrrole is a key intermediate of the dipeptidyl peptidase IV inhibitor vildagliptin (V305000)

(2S)-1-(Chloroacetyl)-2-pyrrolidinecarbonitrile Chemical Properties

Melting point	52-53 °C
Boiling point	363.1±37.0 °C(Predicted)
density	1.27±0.1 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
solubility	Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
form	Solid
pka	-4.65±0.40(Predicted)
color	Pale Yellow to Light Brown
Stability:	Hygroscopic

Safety Information

HS Code

2933998090

Product Application of (2S)-1-(Chloroacetyl)-2-pyrrolidinecarbonitrile CAS#207557-35-5

(2S)-N-chloroacetyl-2-cyano tetrahydropyrrole is a synthetic intermediate of vildagliptin, and is mainly used for the synthesis of vildagliptin. For example, L-prolineamide is used as a raw material, THF is used as a solvent, and K2CO3 is used as an acid-binding agent to carry out a chloroacetylation reaction to obtain (S)-1-(2-chloroacetyl)-2-pyridine carboxamide, and then the amide group is converted into a nitrile by a dehydration cyanation reaction with TFAA to obtain an intermediate (2S)-N-chloroacetyl-2-cyano tetrahydropyrrole. Finally, DCM is used as a solvent, K2CO3 is used as an acid-binding agent, and a condensation reaction is carried out with 3-amino-1-adamantanol, and then column chromatography is used for purification to obtain vildagliptin.

Factory and Equipment Show

Factory and Equipment Show