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Diethyl Malonate 99.5% CAS#105-53-3

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Chemical Name：Diethyl Malonate 99.5%

CAS No.:105-53-3

Molecular Formula:C7H12O4

Molecular weight:160.17

Sample: Available

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Product Details

Products Description of Diethyl Malonate 99.5% CAS#105-53-3

Malonic acid and its derivatives are widely used in pharmaceuticals, spices, food additives, polyester and other industries, and are important fine chemical raw materials and intermediates. Especially in the field of pharmaceutical intermediates, diethyl malonate is widely used in the synthesis of barbian acid, amino acids, vitamins B1, B2 and B6, sleeping drugs, phenylphenylbutazone and other drugs.

Diethyl Malonate Chemical Properties

Melting point	-51--50 °C (lit.)
Boiling point	199 °C (lit.)
density	1.055 g/mL at 25 °C (lit.)
vapor density	5.52 (vs air)
vapor pressure	1 mm Hg ( 40 °C)
refractive index	n20/D 1.413(lit.)
FEMA	2375 \| DIETHYL MALONATE
Fp	212 °F
storage temp.	Store below +30°C.
solubility	20.8g/l (External MSDS)
pka	13.5(at 25℃)
form	Liquid
color	colourless liquid
Odor	Sweet ester odor
Odor Type	fruity
explosive limit	0.8-12.8%(V)
Water Solubility	Miscible with ethyl alcohol, ether, chloroform and benzene. Slightly miscible with water.
Merck	14,3823
JECFA Number	614
BRN	774687
Dielectric constant	7.9（21℃）
Stability:	Stable. Combustible. Incompatible with strong oxidizing agents,
InChIKey	IYXGSMUGOJNHAZ-UHFFFAOYSA-N
LogP	0.96 at 20℃
CAS DataBase Reference	105-53-3(CAS DataBase Reference)
NIST Chemistry Reference	Propanedioic acid, diethyl ester(105-53-3)
EPA Substance Registry System	Diethyl malonate (105-53-3)

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38-36
Safety Statements	24/25-26
WGK Germany	1
RTECS	OO0700000
Autoignition Temperature	435 °C DIN 51794
Hazard Note	Irritant
TSCA	Yes
HS Code	29171910
Hazardous Substances Data	105-53-3(Hazardous Substances Data)
Toxicity	LD50 orally in Rabbit: 15720 mg/kg LD50 dermal Rabbit > 16000 mg/kg

Product Application of Diethyl Malonate 99.5% CAS#105-53-3

It is used as an intermediate for pharmaceutical sulfonamides and barbiturates, as well as for spices and dyes. GB 2760-96 stipulates the edible spices allowed to be used. Mainly used for preparing fruit flavors such as pears, apples, grapes, and cherries. Diethyl malonate is an important intermediate in the preparation of 2-amino-4,6-dimethoxypyrimidine and can be used to prepare sulfonylurea herbicides, such as bensulfuron-methyl, pyrazosulfuron-methyl, and nicosulfuron-methyl. It is also an intermediate used in medicine for sulfa drugs and barbiturates. Diethyl malonate is an organic synthesis intermediate. It is widely used in the production of dyes, spices, sulfonylurea herbicides, etc. Diethyl malonate is mainly used to produce ethoxymethylene, barbituric acid, and alkyl malonate diethyl ester, and then synthesizes medicines such as norfloxacin. Star, lomefloxacin, chloroquine, phenylbutazone, etc. and synthetic dyes and pigments such as benzimidazolone organic pigments. Overseas, diethyl malonate is mainly used to produce ethoxymethylene, barbituric acid and diethyl malonate alkylate. Determination of ammonia and potassium. Gas chromatography stationary solution (maximum operating temperature 40°C, solvents are benzene, chloroform, ethanol). Solvent and plasticizer for resins and nitrocellulose. Organic Synthesis.

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