Bilirubin CAS#635-65-4
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Chemical Name:Bilirubin
CAS No.:635-65-4
Molecular Formula:C33H36N4O6
Molecular weight:584.66
Sample: Available
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Products Description of Bilirubin CAS#635-65-4
This product is mainly derived from the reduction product of heme in hemoglobin through a series of catabolism after the disintegration of aging red blood cells. It is golden yellow or dark reddish brown monoclinic crystal, odorless and tasteless. Soluble in organic solvents such as benzene, chloroform and carbon disulfide; also soluble in hot mixture of ethanol and chloroform; sodium salt is easily soluble in water, but calcium salt, magnesium salt and barium salt are insoluble in water. The dry solid is more stable; the chloroform solution is also more stable in the dark;
It is unstable in alkaline solution (such as 0.1mmol/L sodium hydroxide) or when encountering ferric ions, and is quickly oxidized to biliverdin. The biliverdin can be reduced to bile through in vitro chemical reactions or biliverdin reductase. red pigment. Bilirubin can be combined with glycine, alanine, or histidine. Bilirubin is a strong endogenous antioxidant at normal serum concentrations. The molecular structure of bilirubin can be in two forms: ketone form and alcohol form. Because bilirubin exhibits a specific curled structure, its hydrophobicity is increased and it can enter the interior of lipid molecules. Bilirubin has an extended conjugated double bond system and reactive hydrogen atoms that prevent oxidation. Experiments have shown that bilirubin can inhibit the oxidative modification of LDL (low-density lipoprotein in blood) to a certain extent in vitro, which can inhibit and alleviate the formation of atherosclerosis caused by the oxidative modification of LDL, thereby ultimately preventing and The purpose of treating coronary heart disease.
Bilirubin Chemical Properties
Melting point | 192 °C |
Boiling point | 641.7°C (rough estimate) |
density | 1.2163 (rough estimate) |
refractive index | 1.6000 (estimate) |
storage temp. | -20°C |
solubility | aqueous acid: soluble |
form | powder |
pKa | 4.62±0.10(Predicted) |
color | orange |
Water Solubility | practically insoluble |
Sensitive | Light Sensitive |
Merck | 14,1218 |
BRN | 74376 |
Stability: | Stable. Refrigerate. |
EPA Substance Registry System | Bilirubin (635-65-4) |
Safety Information
Hazard Codes | Xn |
Risk Statements | 62-36/37/38-20/21/22 |
Safety Statements | 22-24/25-36-26 |
WGK Germany | 2 |
RTECS | DU3038000 |
F | 8 |
TSCA | Yes |
HS Code | 29339990 |
Product Application of Bilirubin CAS#635-65-4
Bilirubin is the main component of heme decomposition and the main pigment of bile. It has the functions of an antioxidant and an effective hydrogen peroxide radical scavenger, protecting cell membrane lipids from the oxidation of these active radicals. Generally used in biochemical research, analytical chemistry and synthesis of bezoars. Also acts as an antioxidant, protecting membrane phospholipids from oxidation by hydrogen peroxide free radicals, protecting neurons from oxidative damage even at nanomolar concentrations. Also used for the determination of artificial bezoar bilirubin. Bilirubin has a variety of pharmacological effects and is the main raw material for manufacturing artificial bezoar. Pharmacological experiments have shown that it has a good inhibitory effect on W256 tumor, and its inactivation rate and inhibitory index for Japanese encephalitis virus are 1 to 1.5 times higher than those of deoxycholic acid and cholic acid;
It is also an effective treatment drug for liver diseases. It can proliferate new cells without destroying liver tissue, and can treat serum hepatitis, cirrhosis and other diseases. In addition, bilirubin has the functions of sedation, anticonvulsance, Antipyretic and hypotensive. Promote red blood cell regeneration and other effects.
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