Guaifenesin CAS#93-14-1

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Chemical Name:Guaifenesin

CAS No.:93-14-1

Molecular Formula:C10H14O4

Molecular weight:198.22

Sample: Available

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Product Details

Products Description of Guaifenesin CAS#93-14-1

Guaifenesin, also known as methyl glyceryl benzene diether, guaifenesin, guaifenesin glycerol ether, and glyceryl guaifenesin, is a stimulating expectorant. After oral administration, it can stimulate the gastric mucosa, reflexively cause increased secretion of bronchial mucosal glands, reduce the viscosity of sputum, and make sticky sputum easier to cough up. It is suitable for treating people with a lot of sputum that is difficult to cough up. Guaifenesin has a disinfecting and preservative effect, can reduce the stench of sputum, and also has antitussive, antispasmodic, and anticonvulsant effects. It is used for cough with sputum, lung abscess, bronchiectasis, and secondary asthma in chronic bronchitis, and is often used in combination with other antitussive and antiasthmatic drugs. It can be absorbed from the gastrointestinal tract and reaches a peak blood concentration after 1 to 3 hours. Most of it is excreted from the intestines, and a small amount is metabolized to glucuronic acid conjugates and quickly excreted in the urine.

White crystalline powder. Melting point 78.5-79℃, boiling point 215℃ (2.53kPa). At 25℃, 1g of the product can be dissolved in 20ml of water, soluble in ethanol, chloroform, glycerol, dimethylformamide, easily soluble in benzene, insoluble in petroleum ether. Slightly bitter, with a slightly special smell.


Guaifenesin Chemical Properties

Melting point 

77-81 °C

Boiling point 

215 °C (19 mmHg)

density 

1.1825 (rough estimate)

refractive index 

1.5550 (estimate)

Fp 

215°C/19mm

storage temp. 

2-8°C

solubility 

50g/l (experimental)

pka

13.53±0.20(Predicted)

color 

White to Off-White

Water Solubility 

5 g/100 mL (25 ºC)

Merck 

14,4555

BRN 

2049375

InChIKey

HSRJKNPTNIJEKV-UHFFFAOYSA-N

LogP

1.390

CAS DataBase Reference

93-14-1(CAS DataBase Reference)

NIST Chemistry Reference

3-(O-methoxyphenoxy)-1,2-propanediol(93-14-1)

EPA Substance Registry System

Guaifenesin (93-14-1)

Safety Information

Hazard Codes 

Xn

Risk Statements 

22-36/37/38

Safety Statements 

26-36

WGK Germany 

1

RTECS 

TY8400000

Hazard Note 

Harmful

TSCA 

Yes

HS Code 

29093090

Hazardous Substances Data

93-14-1(Hazardous Substances Data)

Toxicity

LD50 oral in rabbit: 2553mg/kg

Product Application of  Guaifenesin CAS#93-14-1

Guaifenesin is an expectorant and antitussive drug, suitable for chronic bronchitis, bronchiectasis and other diseases with excessive sputum cough.


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Vitamin E CAS#59-02-9


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