2-ACP CAS#36936-23-92 Introduction

2-ACP Introduction

2-ACP, is a chemical compound with the molecular formula C6H6ClN2. It is an important intermediate in the synthesis of various pharmaceuticals and agrochemicals. In this article, we will discuss the properties, applications, and synthesis of 2-ACP.

2-ACP Properties

1. Physical Properties: 2-ACP is a white to off-white crystalline powder with a melting point of 110-114℃. It is soluble in organic solvents such as ethanol, methanol, and acetone, but insoluble in water.

2. Chemical Properties: 2-ACP is a heterocyclic compound containing a pyridine ring and an amino group. It is a weak base and can form salts with acids. It is also susceptible to nucleophilic substitution reactions at the chloro group position.

2-ACP Synthesis

3. Synthesis from 2,6-Dichloropyridine: One of the most common methods for synthesizing 2-ACP is through the reaction of 2,6-dichloropyridine with ammonia in the presence of a catalyst such as Raney nickel or palladium on carbon. The reaction proceeds through a series of steps, including hydrogenation, dechlorination, and cyclization, to form 2-ACP.

4. Synthesis from 2,6-Dichloronicotinic Acid: Another method for synthesizing 2-ACP is through the reaction of 2,6-dichloro nicotinic acid with ammonia in the presence of a reducing agent such as sodium borohydride. The reaction proceeds through a similar series of steps as the previous method to form 2-ACP.

2-ACP Applications

5. Pharmaceutical Intermediates: 2-ACP is an important intermediate in the synthesis of various pharmaceuticals such as antihypertensive agents, antitumor agents, and antiviral agents.

6. Agrochemical Intermediates: 2-ACP is also used as an intermediate in the synthesis of agrochemicals such as herbicides and fungicides.

7. Other Applications: 2-ACP can also be used as a building block in the synthesis of other organic compounds such as dyes and pigments.

2-ACP Conclusion

2-AMINO-5-CHLORO-6-PICOLINE is an important intermediate in the synthesis of various pharmaceuticals and agrochemicals. It can be synthesized through the reaction of 2,6-dichloropyridine or 2,6-dichloronicotinic acid with ammonia. 2-ACP has various applications in the pharmaceutical, agrochemical, and other industries. Its properties and applications make it an important compound in the field of chemistry.

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