Chlorhexidine CAS#55-56-1

Products Description of Chlorhexidine CAS#55-56-1

Used for gingivitis (acute necrotizing ulcerative gingivitis), oral infections after dental surgery, prevention and treatment of oral infections in patients with cancer and leukemia, stomatitis and follicular stomatitis caused by bacterial or fungal oral infections caused by wear of dentures Chemicalbook , Reduce dental plaque. It is also used as a disinfectant for instruments and skin, and a preservative for eye drops.

Product Parameters of Chlorhexidine CAS#55-56-1

1. Names and Identifiers

2.Properties

3. Use and Manufacturing

3.1 Definition

ChEBI: A bisbiguanide compound with a structure consisting of two (p-chlorophenyl)guanide units linked by a hexamethylene bridge.

3.2 History

Chlorhexidine (CHX) was the first antimicrobial agent shown to inhibit dental plaque formation and the development of chronic gingivitis (Loe and Schiott 1970).Chlorhexidine is a cationic chlorophenyl bisbiguanide antiseptic.Bisbiguanides are the primary second generation antiplaque agents exhibiting considerable substantivity and broad spectrum antibacterial properties.In dental medicine, CHX was initially used for disinfection of the oral cavity prior to oral surgical procedures and in endodontics. Plaque inhibition by CHX was first investigated in 1969 (Schroeder) but the first controlled clinical study was performed by Loe and Schiott (1970). [16] This study showed that rinsing for 60 sec, twice a day with 10 ml of a 0.2% (20 mg dose) CHX gluconate solution, in the absence of normal tooth cleaning, inhibited plaque regrowth and the development of gingivitis.CHX is one of the most widely investigated and used antiplaque agents.The advantage of CHX over other cationic agents is that it can bind strongly to many sites in the oral cavity and is released slowly over 7 to 12 hours after rinsing, thus providing considerable substantivity and a sustained antimicrobial effect restricting bacterial proliferation. CHX binds strongly with anionic glycoproteins and phosphoproteins on the oral mucosa and tooth pellicle in addition to its property of binding to the surfaces of bacterial cell membranes affecting the cells ability to adhere. CHX is considered the most potent chemotherapeutic agent currently available.

3.3 Produe Method

Chlorhexidine may be prepared either by condensation ofpolymethylene bisdicyandiamide with 4-chloroaniline hydrochlorideor by condensation of 4-chlorophenyl dicyandiamine withhexamethylenediamine dihydrochloride. Chlorhexidine may also besynthesized from a series of biguanides.

3.4 Usage

Chlorhexidine is an antibacterial used for numerous applications. It is a cationic polybiguanide (bisbiguanide) used primarily as its salts, dihydrochloride, diacetate, and digluconate. Chlorhexidine is one of those drugs which are enlisted/included in the World Health Organization's List of Essential Medicines, a list of the most important drugs needed in a basic health system.Chlorhexidine is used as a germicidal compound in teat dips. Also used as navel treatment, udder and eye wash, surgical scrub and sterilization material.Chlorhexidine is used primarily as a topical antiseptic/disinfectant in wound healing, at catheterization sites, in various dental applications and in surgical scrubs. it is used as an antibacterial agent in humans to control gingivitis and over all plaque control in preventative dentistry.Hydrogenolysis of benzyl-nitrogen bonds.Bacteriostatic;Detergent.

4. Safety and Handling

4.1 Hazard Codes

Xi,N

4.1 Risk Statements

36/37/38-43-51/53-50/53

4.1 Safety Statements

26-36/37-60-61

4.1 Exposure Standards and Regulations

The Approved Drug Products with Therapeutic Equivalence Evaluations List identifies currently marketed prescription and over-the-counter drug products, incl chlorhexidine gluconate, approved on the basis of safety and effectiveness by FDA under sections 505 of the Federal Food, Drug, and Cosmetic Act. /Chlorhexidine gluconate/
Ophthalmic and topical dosage form new animal drugs. Chlorhexidine ointment. The product contains 1% chlorhexidine acetate in an ointment base. Indications for use: use as a topical antiseptic ointment for surface wounds on dogs, cats, and horses. Limitations: Not for use in horses intended for food.
Certain other dosage form new animal drugs. chlorhexidine tablets and suspension. Each tablet and each 28-mL syringe of suspension contain 1 g of chlorhexidine dihydrochloride. Indications for use: for prevention or treatment of metritis and vaginitis in cows and mares when caused by pathogens sensitive to chlorhexidine dihydrochloride.
Tolerances for residues of new animal drugs in food. A tolerance of zero is established for residues of chlorhexidine in the uncooked edible tissues of calves.

Product Application of Chlorhexidine CAS#55-56-1

· Used for gingivitis (acute necrotizing ulcerative gingivitis), oral infections after dental surgery, prevention and treatment of oral infections in patients with cancer and leukemia, stomatitis and follicular stomatitis caused by bacterial or fungal oral infections caused by wear of dentures Chemicalbook , Reduce dental plaque. It is also used as a disinfectant for instruments and skin, and a preservative for eye drops.

· It is a surfactant type bactericide with strong broad-spectrum bacteriostatic and bactericidal effects, and is effective against both Gram-positive and Gram-negative bacteria.

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