Clavulanic acid CAS#58001-44-8

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Chemical Name:Clavulanic acid

CAS No.58001-44-8

Molecular Formula:58001-44-8

Molecular weight:C8H9NO5

Sample: Available

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Product Details

Products Description of Clavulanic acid CAS#58001-44-8

Clavulanate Potassium, trade name potassium clavulanate, is an oxopenicillin β-lactamase inhibitor, which is a β-lactam ring and a hydrogenated isoxazole ring. It is a suicidal enzyme inhibitor.



Clavulanic acid Chemical Properties

Boiling point 

545.8±50.0 °C(Predicted)

density 

1.65±0.1 g/cm3(Predicted)

storage temp. 

4°C, protect from light, stored under nitrogen

solubility 

H2O : 50 mg/mL (251.05 mM; Need ultrasonic)

pka

3.68±0.20(Predicted)

Product Application of Clavulanic acid CAS#58001-44-8

It is a β-lactamase inhibitor. It has only weak antibacterial activity itself, but it has an inhibitory effect on β-lactamase produced by staphylococci and most Gram-negative bacteria. It firmly binds to β-lactamase to form an irreversible conjugate, which makes the enzyme inactive. Therefore, when used in combination with β-lactam antibiotics, it can protect the combined β-lactam antibiotics from being destroyed by β-lactamase, enhance the antibacterial effect of the antibiotics, expand its antibacterial spectrum, and overcome the drug resistance of pathogenic microorganisms. Its application is to make a complex with other antibiotics, such as when it is combined with amoxicillin, it is called Augmentin; when it is combined with ticarcillin, it is called Timentin.


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