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4,4'-Diaminodiphenylsulfone CAS#80-08-0

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Chemical Name：4,4'-Diaminodiphenylsulfone

CAS No.:80-08-0

Molecular Formula：C12H12N2O2S

Molecular weight:248.3

Sample: Available

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Product Details

Products Description of 4,4'-Diaminodiphenylsulfone CAS#80-08-0

Dapsone is a sulfone antibacterial drug with a strong antibacterial effect on Mycobacterium leprae. Its preparations have been widely used in the treatment of leprosy. As the first choice for the treatment of leprosy, dapsone acts on the dihydrofolate synthase (DHPs) of bacteria, interferes with the synthesis of folic acid, and affects the synthesis of protein by bacteria. In addition, dapsone also has an anti-inflammatory effect, and has a significant scavenging effect on toxic oxygen free radicals and other substances produced after neutrophils are stimulated. At the same time, it can also inhibit the aggregation and activation of neutrophils, reduce the release of inflammatory mediators, and thus reduce damage to the body. Studies have shown that the blood concentration achieved by oral administration of 100 mg of dapsone is 500-600 times the minimum inhibitory concentration required to inhibit Mycobacterium leprae. In recent years, studies have found that dapsone can also be used for other infectious diseases, inflammatory skin diseases, autoimmune bullous diseases, urticaria, etc., and its indications are very wide.

4,4'-Diaminodiphenylsulfone Chemical Properties

Melting point	175-177 °C(lit.)
Boiling point	511.7±35.0 °C(Predicted)
density	1.2701 (rough estimate)
vapor pressure	0.004Pa at 25℃
refractive index	1.5950 (estimate)
storage temp.	2-8°C
solubility	0.38g/l
form	Crystalline Powder
pka	pKb 13.0(at 25℃)
color	White to beige
PH	5.5-7.5 (H2O, 20℃)(saturated aqueous solution)
Water Solubility	<0.1 g/100 mL at 20 ºC
Merck	14,2822
BRN	788055
BCS Class	4,2
Stability:	Stable. Combustible. Incompatible with strong oxidizing agents.
InChIKey	MQJKPEGWNLWLTK-UHFFFAOYSA-N
LogP	0.97 at 25℃
CAS DataBase Reference	80-08-0(CAS DataBase Reference)
NIST Chemistry Reference	Dapsone(80-08-0)
IARC	3 (Vol. 24, Sup 7) 1987
EPA Substance Registry System	Dapsone (80-08-0)

Safety Information

Hazard Codes	Xn
Risk Statements	22
Safety Statements	22
RIDADR	3249
WGK Germany	1
RTECS	BY8925000
TSCA	Yes
HazardClass	6.1(b)
PackingGroup	III
HS Code	29051620
HS Code	29309070
Hazardous Substances Data	80-08-0(Hazardous Substances Data)
Toxicity	LD50 orally in Rabbit: 1000 mg/kg LD50 dermal Rabbit > 4000 mg/kg

Product Application of 4,4'-Diaminodiphenylsulfone CAS#80-08-0

4,4'-Diaminodiphenyl sulfone is an important aromatic sulfone compound refined by high temperature and high pressure amination reaction. It is mainly used in the synthesis of polysulfoneamide resins and other polymer synthetic materials, and the synthesis of various acidic azo dyes and disperse dyes. It can be used as an epoxy resin curing agent and insulating materials in the electrical industry, textile equipment, and can also be used as a catalyst. It can also be used in the pharmaceutical industry to treat leprosy, herpetiform dermatitis, AIDS, etc.

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