4-Dimethylaminopyridine CAS#1122-58-3

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Chemical Name:4-Dimethylaminopyridine

CAS No.:1122-58-3

Molecular Formula:C7H10N2

Molecular weight:122.17

Sample: Available

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Product Details

Products Description of 4-Dimethylaminopyridine CAS#1122-58-3

4-dimethylaminopyridine, commonly referred to as DMAP, is a strong nucleophilic acylation catalyst. The resonance of the electron-donating dimethylamino group with the parent ring (pyridine ring) can strongly activate the nitrogen atoms on the ring for nucleophilic substitution, and significantly catalyze the acylation/esterification of alcohols and amines/acids with high resistance and low reactivity, with the activity of about 104~106 times that of pyridine. Acyl transfer is a common transformation in nature and organic synthesis, in which chiral DMAP is a common asymmetric acyl transfer catalyst.




4-Dimethylaminopyridine Chemical Properties

Melting point 

112 °C

Boiling point 

162 °C

density 

0.906 g/mL at 25 °C

vapor pressure 

0.169 hPa at 20 °C

refractive index 

n20/D 1.431

Fp 

110 °C

storage temp. 

Store below +30°C.

solubility 

methanol: 50 mg/mL, clear

form 

prilled

pka

pKa (20°): 9.7

color 

off-white to yellow

Odor

characteristic odor

PH Range

9.7 (10% aq soln)

PH

11 (60g/l, H2O, 20℃)

Water Solubility 

76 g/L (25 ºC)

Merck 

14,3389

BRN 

110354

Stability:

Stable. Incompatible with acids, oxidizing agents.

LogP

1.34 at 25℃

CAS DataBase Reference

1122-58-3(CAS DataBase Reference)

NIST Chemistry Reference

4-Pyridinamine, N,N-dimethyl-(1122-58-3)

EPA Substance Registry System

4-(Dimethylamino)pyridine (1122-58-3)

Safety Information


Hazard Codes 

T,C,T+,Xn,F

Risk Statements 

25-34-24/25-36/37/38-27-36-24-20-61-40-23/24/25-67-66-21/22-11-36/37-22-19

Safety Statements 

36/37/39-45-28A-26-28-36/37-53-27-22-16

RIDADR 

UN 2811 6.1/PG 2

WGK Germany 

3

RTECS 

US8400000

Autoignition Temperature

420 °C

Hazard Note 

Toxic/Corrosive

TSCA 

T

HazardClass 

8

PackingGroup 

II

HS Code 

29333999

Toxicity

LD50 orally in Rabbit: 140 mg/kg LD50 dermal Rabbit 90 mg/kg


Product Application of 4-Dimethylaminopyridine CAS#1122-58-3

Used for softening water, preparing high-purity water, refining radioactive elements, extracting iodine from seaweed, refining antibiotics, industrial wastewater treatment, etc.


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Vitamin E CAS#59-02-9



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