4-Dimethylaminopyridine CAS#1122-58-3
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Chemical Name:4-Dimethylaminopyridine
CAS No.:1122-58-3
Molecular Formula:C7H10N2
Molecular weight:122.17
Sample: Available
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Products Description of 4-Dimethylaminopyridine CAS#1122-58-3
4-dimethylaminopyridine, commonly referred to as DMAP, is a strong nucleophilic acylation catalyst. The resonance of the electron-donating dimethylamino group with the parent ring (pyridine ring) can strongly activate the nitrogen atoms on the ring for nucleophilic substitution, and significantly catalyze the acylation/esterification of alcohols and amines/acids with high resistance and low reactivity, with the activity of about 104~106 times that of pyridine. Acyl transfer is a common transformation in nature and organic synthesis, in which chiral DMAP is a common asymmetric acyl transfer catalyst.
4-Dimethylaminopyridine Chemical Properties
Melting point | 112 °C |
Boiling point | 162 °C |
density | 0.906 g/mL at 25 °C |
vapor pressure | 0.169 hPa at 20 °C |
refractive index | n20/D 1.431 |
Fp | 110 °C |
storage temp. | Store below +30°C. |
solubility | methanol: 50 mg/mL, clear |
form | prilled |
pka | pKa (20°): 9.7 |
color | off-white to yellow |
Odor | characteristic odor |
PH Range | 9.7 (10% aq soln) |
PH | 11 (60g/l, H2O, 20℃) |
Water Solubility | 76 g/L (25 ºC) |
Merck | 14,3389 |
BRN | 110354 |
Stability: | Stable. Incompatible with acids, oxidizing agents. |
LogP | 1.34 at 25℃ |
CAS DataBase Reference | 1122-58-3(CAS DataBase Reference) |
NIST Chemistry Reference | 4-Pyridinamine, N,N-dimethyl-(1122-58-3) |
EPA Substance Registry System | 4-(Dimethylamino)pyridine (1122-58-3) |
Safety Information
Hazard Codes | T,C,T+,Xn,F |
Risk Statements | 25-34-24/25-36/37/38-27-36-24-20-61-40-23/24/25-67-66-21/22-11-36/37-22-19 |
Safety Statements | 36/37/39-45-28A-26-28-36/37-53-27-22-16 |
RIDADR | UN 2811 6.1/PG 2 |
WGK Germany | 3 |
RTECS | US8400000 |
Autoignition Temperature | 420 °C |
Hazard Note | Toxic/Corrosive |
TSCA | T |
HazardClass | 8 |
PackingGroup | II |
HS Code | 29333999 |
Toxicity | LD50 orally in Rabbit: 140 mg/kg LD50 dermal Rabbit 90 mg/kg |
Product Application of 4-Dimethylaminopyridine CAS#1122-58-3
Used for softening water, preparing high-purity water, refining radioactive elements, extracting iodine from seaweed, refining antibiotics, industrial wastewater treatment, etc.
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