2-(Methylamino)pyridine CAS#4597-87-9

2-(Methylamino)pyridine Introduction

It, also known as MAP, is a chemical compound with the molecular formula C6H8N2. It is commonly used in the pharmaceutical and chemical industries as a building block for various drugs and chemicals. In this article, we will explore the properties, applications, and synthesis of 2-(Methylamino)pyridine.

2-(Methylamino)pyridine Properties

1. Physical properties: it is a colorless to pale yellow liquid with a pungent odor. It has a boiling point of 208-209°C and a melting point of -35°C.

2. Chemical properties: it is a basic compound and can act as a nucleophile in various chemical reactions. It is also a good ligand for transition metal catalysts.

3. Safety: it is a hazardous material and should be handled with care. It can cause skin and eye irritation and is toxic if ingested or inhaled.

2-(Methylamino)pyridine Applications

1. Pharmaceutical industry: it is used as a building block for various drugs, such as antihistamines, antipsychotics, and antidepressants.

2. Chemical industry: it is used as a catalyst in various chemical reactions, such as the synthesis of polymers and the production of agrochemicals.

3. Research: it is used as a ligand in various research studies, such as the development of new catalysts and the study of metal-ligand interactions.

2-(Methylamino)pyridine Synthesis

1. One-pot synthesis: it can be synthesized in a one-pot reaction by reacting 2-chloropyridine with formaldehyde and methylamine.

2. Two-step synthesis: it can also be synthesized in a two-step reaction by first reacting 2-chloropyridine with sodium methoxide to form 2-pyridylmethanol, which is then reacted with methylamine to form 2-(Methylamino)pyridine.

3. Other methods: it can also be synthesized using other methods, such as the reaction of 2-bromopyridine with methylamine or the reaction of 2-pyridylmagnesium bromide with formaldehyde and methylamine.

2-(Methylamino)pyridine Conclusion

This is a versatile chemical compound that has many applications in the pharmaceutical and chemical industries. Its unique properties make it a valuable building block for various drugs and chemicals. However, due to its hazardous nature, it should be handled with care and proper safety precautions should be taken. With its numerous applications and potential for further research, 2-(Methylamino)pyridine is an important compound in the field of chemistry.

Introduction

2-(Methylamino)pyridine, also known as MAP, is a chemical compound with the molecular formula C6H8N2. It is commonly used in the pharmaceutical and chemical industries as a building block for various drugs and chemicals. In this article, we will explore the properties, applications, and synthesis of 2-(Methylamino)pyridine.

Properties

1. Physical properties: 2-(Methylamino)pyridine is a colorless to pale yellow liquid with a pungent odor. It has a boiling point of 208-209°C and a melting point of -35°C.

2. Chemical properties: 2-(Methylamino)pyridine is a basic compound and can act as a nucleophile in various chemical reactions. It is also a good ligand for transition metal catalysts.

3. Safety: 2-(Methylamino)pyridine is a hazardous material and should be handled with care. It can cause skin and eye irritation and is toxic if ingested or inhaled.

Applications

1. Pharmaceutical industry: 2-(Methylamino)pyridine is used as a building block for various drugs, such as antihistamines, antipsychotics, and antidepressants.

2. Chemical industry: 2-(Methylamino)pyridine is used as a catalyst in various chemical reactions, such as the synthesis of polymers and the production of agrochemicals.

3. Research: 2-(Methylamino)pyridine is used as a ligand in various research studies, such as the development of new catalysts and the study of metal-ligand interactions.

Synthesis

1. One-pot synthesis: 2-(Methylamino)pyridine can be synthesized in a one-pot reaction by reacting 2-chloropyridine with formaldehyde and methylamine.

2. Two-step synthesis: 2-(Methylamino)pyridine can also be synthesized in a two-step reaction by first reacting 2-chloropyridine with sodium methoxide to form 2-pyridylmethanol, which is then reacted with methylamine to form 2-(Methylamino)pyridine.

3. Other methods: 2-(Methylamino)pyridine can also be synthesized using other methods, such as the reaction of 2-bromopyridine with methylamine or the reaction of 2-pyridylmagnesium bromide with formaldehyde and methylamine.

Conclusion

2-(Methylamino)pyridine is a versatile chemical compound that has many applications in the pharmaceutical and chemical industries. Its unique properties make it a valuable building block for various drugs and chemicals. However, due to its hazardous nature, it should be handled with care and proper safety precautions should be taken. With its numerous applications and potential for further research, 2-(Methylamino)pyridine is an important compound in the field of chemistry.

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