Methotrexate CAS#59-05-2

Products Description of Methotrexate CAS#59-05-2

This product is a good anti-tumor drug and is used for acute lymphoblastic leukemia, lymphoma, malignant hydatidiform mole, choriocarcinoma, squamous cell carcinoma, lung cancer, cervical cancer, breast cancer and osteosarcoma Chemicalbook. 90% of the original drug of methotrexate is excreted in the urine 12 hours after oral administration, and the main metabolite is 7-hydroxymethotrexate. The LD50 of intravenous injection in rats is 14mg/kg.

Product Parameters of Methotrexate CAS#59-05-2

1. Names and Identifiers

2. Properties

3. Use and Manufacturing

3.1 Potential Exposure

Methotrexate is an alkaloid anticancerdrug available in tablet or injectable liquid form. A chemotherapy drug that interferes with DNA and RNA synthesis.It is also an insect chemosterilant.

3.2 Purification Methods

Most common impurities are 10-methylpteroylglutamic acid, aminopterin and pteroylglutamic acid. Purify it by chromatography on Dowex-1 acetate, followed by filtration through a mixture of cellulose and charcoal. It has been recrystallised from aqueous HCl or by dissolution in the minimum volume of N NaOH and acidified until precipitation is complete, filter or better collect by centrifugation, wash with H2O (also by centrifugation) and dry at 100o/3mm. It has UV: max at 244 and 307nm ( 17300 and 19700) in H2O at pH 1; 257, 302 and 370nm ( 23000, 22000 and 7100) in 2O at pH 13. [Momle Biochemical Preparations 8 20 1961, Seeger et al. J Am Chem Soc 71 1753 1949.] It is a potent inhibitor of dihydrofolate reductase and is used in cancer chemotherapy. [Blakley The Biochemistry of Folic Acid and Related Pteridines, North-Holland Publ Co., Amsterdam, NY, pp157-163 1969, Beilstein 26 IV 3833.] It is CARCINOGENIC; HANDLE WITH EXTREME CARE.

3.3 Shipping

UN1544 Alkaloids, solid, n.o.s. or Alkaloid salts,solid, n.o.s. poisonous, Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required. UN2811Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.

3.4 Usage

Used as a antineoplastic and antirheumatic. A folic Acid antagonist

3.5 Waste Disposal

It is inappropriate and possibly dangerous to the environment to dispose of expired orwaste drugs and pharmaceuticals by flushing them downthe toilet or discarding them to the trash. Household quantities of expired or waste pharmaceuticals may be mixedwith wet cat litter or coffee grounds, double-bagged inplastic, discard in trash. Larger quantities shall carefullytake into consideration applicable DEA, EPA, and FDAregulations. If possible return the pharmaceutical to themanufacturer for proper disposal being careful to properlylabel and securely package the material. Alternatively, thewaste pharmaceutical shall be labeled, securely packaged and transported by a state licensed medical waste contractorto dispose by burial in a licensed hazardous or toxic wastelandfill or incinerator.

4.Safety and Handling

4.1 Symbol

GHS06, GHS08

4.1 Hazard Codes

T

4.1 Signal Word

Danger

4.1 Risk Statements

R61;R25;R36/38

4.1 Safety Statements

S53;S26;S36/37;S45

4.1 Exposure Standards and Regulations

The Approved Drug Products with Therapeutic Equivalence Evaluations List identifies currently marketed prescription drug products, incl methotrexate sodium, approved on the basis of safety and effectiveness by FDA under sections 505 of the Federal Food, Drug, and Cosmetic Act. /Methotrexate Sodium/

4.2 Packing Group

III

4.2 Octanol/Water Partition Coefficient

log Kow = -1.85

4.3 Fire Hazard

Flash point data for Methotrexate are not available; however, Methotrexate is probably combustible.

4.4 Hazard Class

6.1(b)

4.4 Hazard Declaration

H301-H315-H319-H340-H360

4.4 DisposalMethods

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.

Product Application of Methotrexate CAS#59-05-2

1. The treatment of leukemia used to be administered daily, with adults taking 2.5 to 10 mg/d orally, with a total dose of 50 to 150 mg. Children 1.25~5mg/d, recent trends tend to use a large number of intermittent dosing therapy, dosing therapy, that is, oral or intramuscular injection twice a week, 0.25~0.75mg/kg each time, adults generally 20~25mg each time, intrathecally Injection: 10 to 15 mg/time; children use 6 to 12 mg/time according to age, once a day for treatment, for 3 days; once every 4 to 8 weeks for prevention.

2. For chorioepithelial carcinoma, adults generally take 10 to 30 mg, orally or intramuscularly, once a day for 5 consecutive days. The course of treatment can be repeated later depending on the patient's response.

3. For solid cancer, it is best to use continuous intra-arterial infusion and at the same time give intermittent intramuscular injection of leucovorin (CF). The usual dosage is 25-50mg/d of this product, 6-9mg of CF, 1 intramuscular injection every 4-6 hours. Second-rate.

4. For osteosarcoma, use high doses and cooperate with CF detoxification. Generally, the dosage of this product is 3~20g/m2, dissolved in 500~1000ml of 5% glucose injection, and infused intravenously for 4 hours. Start applying CF 2 to 6 hours after the infusion, with a dose of 6 to 12 mg intramuscularly (or orally), once every 6 hours for a total of 3 days. In order to ensure that the drug can be quickly excreted from the body, electrolytes, water and sodium bicarbonate should be supplemented in the first 1 day and every 1 to 2 days of infusion, so that the urine output exceeds 3000ml per day, and ensure that it is alkaline. Liver function, kidney function, blood images and plasma methotrexate concentration should be tested daily.

5. It is rarely used to treat psoriasis due to severe side effects. To treat psoriasis, take 1.25mg orally each time, 2 to 3 times a day. A course of treatment lasts for 6 to 9 days.

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